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Case Study: Runner Finds Relief from Knee Pain with MACI

Case Study: Runner Finds Relief from Knee Pain with MACI

Surgeons who perform the MACI knee procedure will see many different knee cartilage repair case studies cross their desks. Dr. Deryk Jones of Ochsner Sports Medicine Institute shares a recent case.

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Surgical Best Practices for a Knee Arthroscopy and MACI Cartilage Biopsy

Surgical Best Practices for a Knee Arthroscopy and MACI Cartilage Biopsy

The first step in treating knee cartilage damage via MACI is an arthroscopy. The knee arthroscopy allows a physician to scope the knee and harvest a biopsy of a patient’s cartilage cells, which are later used to generate a MACI knee cartilage implant.

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How MACI Helped One Nurse Make Her Comeback from Knee Pain

How MACI Helped One Nurse Make Her Comeback from Knee Pain

MACI patient Kayla is a registered nurse, and to orthopedic surgeon Dr. Seth Sherman, she offers a uniquely valuable perspective on knee cartilage treatment: “There’s no better way to learn about MACI than from a healthcare provider who went through it!”

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Understanding Surgical Best Practices for MACI Knee Cartilage Repair

Understanding Surgical Best Practices for MACI Knee Cartilage Repair

MACI knee cartilage repair is the third generation of autologous chondrocyte implantation (ACI), and it advances upon previous ACIs by offering surgeons a simpler, shorter and more versatile procedure to repair patients’ articular cartilage defects of the knee using an implant generated from their own cartilage cells (prior generations of ACI required a periosteum or collagen membrane cover).

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Indication

MACI® (autologous cultured chondrocytes on porcine collagen membrane) is an autologous cellularized scaffold product that is indicated for the repair of single or multiple symptomatic, full-thickness cartilage defects of the adult knee, with or without bone involvement.

MACI is intended for autologous use and must only be administered to the patient for whom it was manufactured. The implantation of MACI is to be performed via an arthrotomy to the knee joint under sterile conditions.

The amount of MACI administered is dependent upon the size (surface in cm²) of the cartilage defect. The implantation membrane is trimmed by the treating surgeon to the size and shape of the defect, to ensure the damaged area is completely covered, and implanted cell-side down.

Limitations of Use

Effectiveness of MACI in joints other than the knee has not been established.

Safety and effectiveness of MACI in patients over the age of 55 years have not been established.

Important safety information

MACI is contraindicated in patients with a known history of hypersensitivity to gentamicin, other aminoglycosides, or products of porcine or bovine origin. MACI is also contraindicated for patients with severe osteoarthritis of the knee, inflammatory arthritis, inflammatory joint disease, or uncorrected congenital blood coagulation disorders. MACI is also not indicated for use in patients who have undergone prior knee surgery in the past 6 months, excluding surgery to procure a biopsy or a concomitant procedure to prepare the knee for a MACI implant.

MACI is contraindicated in patients who are unable to follow a physician-prescribed post-surgical rehabilitation program.

The safety of MACI in patients with malignancy in the area of cartilage biopsy or implant is unknown. Expansion of present malignant or dysplastic cells during the culturing process or implantation is possible.

Patients undergoing procedures associated with MACI are not routinely tested for transmissible infectious diseases. A cartilage biopsy and MACI implant may carry the risk of transmitting infectious diseases to healthcare providers handling the tissue. Universal precautions should be employed when handling the biopsy samples and the MACI product.

Final sterility test results are not available at the time of shipping. In the case of positive sterility results, health care provider(s) will be contacted.

To create a favorable environment for healing, concomitant pathologies that include meniscal pathology, cruciate ligament instability and joint misalignment, must be addressed prior to or concurrent with the implantation of MACI.

Local treatment guidelines regarding the use of thromboprophylaxis and antibiotic prophylaxis around orthopaedic surgery should be followed. Use in patients with local inflammations or active infections in the bone, joint, and surrounding soft tissue should be temporarily deferred until documented recovery.

The MACI implant is not recommended during pregnancy. For implantations post-pregnancy, the safety of breast feeding to infant has not been determined.

Use of MACI in pediatric patients (younger than 18 years of age) or patients over 65 years of age has not been established.

The most frequently occurring adverse reactions reported for MACI (≥5%) were arthralgia, tendonitis, back pain, joint swelling, and joint effusion.

Serious adverse reactions reported for MACI were arthralgia, cartilage injury, meniscus injury, treatment failure, and osteoarthritis.

Please see Full Prescribing Information for more information